Journal article
Immune imprinting in early life shapes cross-reactivity to influenza B virus haemagglutinin
P Edler, LSU Schwab, M Aban, M Wille, N Spirason, YM Deng, MA Carlock, TM Ross, JA Juno, S Rockman, AK Wheatley, SJ Kent, IG Barr, DJ Price, M Koutsakos
Nature Microbiology | NATURE PORTFOLIO | Published : 2024
Abstract
Influenza exposures early in life are believed to shape future susceptibility to influenza infections by imprinting immunological biases that affect cross-reactivity to future influenza viruses. However, direct serological evidence linked to susceptibility is limited. Here we analysed haemagglutination-inhibition titres in 1,451 cross-sectional samples collected between 1992 and 2020, from individuals born between 1917 and 2008, against influenza B virus (IBV) isolates from 1940 to 2021. We included testing of ‘future’ isolates that circulated after sample collection. We show that immunological biases are conferred by early life IBV infection and result in lineage-specific cross-reactivity o..
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Grants
Awarded by Morningside Foundation
Funding Acknowledgements
We thank the participants for their generous involvement and provision of samples. We are grateful to the CSL investigators who originally initiated this study NCT00959049 trial. We are grateful to M. Vieira, K. Gostic and S. Cobey for discussions and advice on data analysis. This study has been generously supported by the Morningside Foundation and by Australian National Health and Medical Research Council Investigator grants (1195698 to M.K., 1173433 to A.K.W., 2009308 to J.A.J. and 1136322 to S.J.K.). The WHOCCRRI is supported by the Australian Government Department of Health. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the paper.